Comparative Outcomes of Induction Chemotherapy Followed By Definitive Chemoradiotherapy versus Chemoradiotherapy Alone In Esophageal Squamous Cell Carcinoma

Purpose: To compare the clinical outcomes of induction chemotherapy (IC) followed by chemoradiotherapy (CRT) versus chemoradiotherapy alone in patients with locally advanced esophageal squamous cell carcinoma (ESCC). Patients and methods: Between 2002 and 2015, 267 ESCC patients who received definit...

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Publicado no:J Cancer
Main Authors: Luo, Li-Ling, Xi, Mian, Yang, Ya-Di, Li, Qiao-Qiao, Zhao, Lei, Zhang, Peng, Liu, Shi-Liang, Liu, Meng-Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687157/
https://ncbi.nlm.nih.gov/pubmed/29151927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.21131
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spelling pubmed-56871572017-11-18 Comparative Outcomes of Induction Chemotherapy Followed By Definitive Chemoradiotherapy versus Chemoradiotherapy Alone In Esophageal Squamous Cell Carcinoma Luo, Li-Ling Xi, Mian Yang, Ya-Di Li, Qiao-Qiao Zhao, Lei Zhang, Peng Liu, Shi-Liang Liu, Meng-Zhong J Cancer Research Paper Purpose: To compare the clinical outcomes of induction chemotherapy (IC) followed by chemoradiotherapy (CRT) versus chemoradiotherapy alone in patients with locally advanced esophageal squamous cell carcinoma (ESCC). Patients and methods: Between 2002 and 2015, 267 ESCC patients who received definitive CRT with docetaxel and cisplatin were enrolled in this study. Through a matched case-control study, 85 patients receiving IC before CRT were matched 1:1 to patients who received CRT alone, according to age, gender, performance status, tumor location, tumor length, and pretreatment TNM stage. Results: The median overall survival (OS) in the IC group was significantly better than that in the CRT group (26.0 vs. 22.0 months), with 3-year OS rates of 30.6% vs. 25.9%, respectively (P = 0.028). However, IC plus CRT was associated with a significantly higher rate of grade 3-4 leukopenia than CRT alone (P = 0.048). The overall clinical response rate was 50.6% after IC in the IC group. The IC responder group showed significantly more favorable OS (P=0.002) and progression-free survival (P=0.001) compared with the IC non-responder group and the CRT group. Multivariate analysis revealed that age ≥ 60 (P = 0.003) and the addition of IC (P=0.016) were independent prognostic factors that affected survival positively. Conclusions: The addition of IC before CRT yielded satisfactory clinical outcomes and manageable toxicities. The combination of IC with CRT might be a promising treatment strategy to further improve systemic control and survival in ESCC. Prospective randomized trials are required to confirm the role of IC. Ivyspring International Publisher 2017-09-20 /pmc/articles/PMC5687157/ /pubmed/29151927 http://dx.doi.org/10.7150/jca.21131 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Research Paper
spellingShingle Research Paper
Luo, Li-Ling
Xi, Mian
Yang, Ya-Di
Li, Qiao-Qiao
Zhao, Lei
Zhang, Peng
Liu, Shi-Liang
Liu, Meng-Zhong
Comparative Outcomes of Induction Chemotherapy Followed By Definitive Chemoradiotherapy versus Chemoradiotherapy Alone In Esophageal Squamous Cell Carcinoma
description Purpose: To compare the clinical outcomes of induction chemotherapy (IC) followed by chemoradiotherapy (CRT) versus chemoradiotherapy alone in patients with locally advanced esophageal squamous cell carcinoma (ESCC). Patients and methods: Between 2002 and 2015, 267 ESCC patients who received definitive CRT with docetaxel and cisplatin were enrolled in this study. Through a matched case-control study, 85 patients receiving IC before CRT were matched 1:1 to patients who received CRT alone, according to age, gender, performance status, tumor location, tumor length, and pretreatment TNM stage. Results: The median overall survival (OS) in the IC group was significantly better than that in the CRT group (26.0 vs. 22.0 months), with 3-year OS rates of 30.6% vs. 25.9%, respectively (P = 0.028). However, IC plus CRT was associated with a significantly higher rate of grade 3-4 leukopenia than CRT alone (P = 0.048). The overall clinical response rate was 50.6% after IC in the IC group. The IC responder group showed significantly more favorable OS (P=0.002) and progression-free survival (P=0.001) compared with the IC non-responder group and the CRT group. Multivariate analysis revealed that age ≥ 60 (P = 0.003) and the addition of IC (P=0.016) were independent prognostic factors that affected survival positively. Conclusions: The addition of IC before CRT yielded satisfactory clinical outcomes and manageable toxicities. The combination of IC with CRT might be a promising treatment strategy to further improve systemic control and survival in ESCC. Prospective randomized trials are required to confirm the role of IC.
author Luo, Li-Ling
Xi, Mian
Yang, Ya-Di
Li, Qiao-Qiao
Zhao, Lei
Zhang, Peng
Liu, Shi-Liang
Liu, Meng-Zhong
author_facet Luo, Li-Ling
Xi, Mian
Yang, Ya-Di
Li, Qiao-Qiao
Zhao, Lei
Zhang, Peng
Liu, Shi-Liang
Liu, Meng-Zhong
author_sort Luo, Li-Ling
title Comparative Outcomes of Induction Chemotherapy Followed By Definitive Chemoradiotherapy versus Chemoradiotherapy Alone In Esophageal Squamous Cell Carcinoma
title_short Comparative Outcomes of Induction Chemotherapy Followed By Definitive Chemoradiotherapy versus Chemoradiotherapy Alone In Esophageal Squamous Cell Carcinoma
title_full Comparative Outcomes of Induction Chemotherapy Followed By Definitive Chemoradiotherapy versus Chemoradiotherapy Alone In Esophageal Squamous Cell Carcinoma
title_fullStr Comparative Outcomes of Induction Chemotherapy Followed By Definitive Chemoradiotherapy versus Chemoradiotherapy Alone In Esophageal Squamous Cell Carcinoma
title_full_unstemmed Comparative Outcomes of Induction Chemotherapy Followed By Definitive Chemoradiotherapy versus Chemoradiotherapy Alone In Esophageal Squamous Cell Carcinoma
title_sort comparative outcomes of induction chemotherapy followed by definitive chemoradiotherapy versus chemoradiotherapy alone in esophageal squamous cell carcinoma
publisher Ivyspring International Publisher
container_title J Cancer
publishDate 2017
url https://ncbi.nlm.nih.gov/pmc/articles/PMC5687157/
https://ncbi.nlm.nih.gov/pubmed/29151927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.21131
_version_ 1820311404881641472

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