Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage

BACKGROUND: ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteins play an important pathological role in matrix degeneration. Aggrecan degradation is a significant and critical event in early-stage osteoarthritis. To determine the effect of hemoglobin (Hb) on the ability of...

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Bibliografiske detaljer
Udgivet i:BMC Musculoskelet Disord
Main Authors: Tajima, Takuya, Sekimoto, Tomohisa, Yamaguchi, Nami, Taniguchi, Noboru, Kurogi, Syuji, Maruyama, Masugi, Chosa, Etsuo
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686793/
https://ncbi.nlm.nih.gov/pubmed/29137610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-017-1815-7
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