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Analysis of LINE-1 Elements in DNA from Postmortem Brains of Individuals with Schizophrenia

Whereas some rare genetic variants convey high risk for schizophrenia (SZ), common alleles conveying even moderate risk remain elusive. Long interspersed element-1s (L1) are mobile retrotransposons comprising ~17% of the human genome. L1 retrotransposition can cause somatic mosaicism during neurodev...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Doyle, Glenn A, Crist, Richard C, Karatas, Emre T, Hammond, Matthew J, Ewing, Adam D, Ferraro, Thomas N, Hahn, Chang-Gyu, Berrettini, Wade H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686486/
https://ncbi.nlm.nih.gov/pubmed/28585566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.115
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