ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y(12) in platelets

Tumor metastasis is the major cause of deaths in cancer patients and is modulated by intertwined stress-responsive signaling cascades. Here we demonstrate that deletion of stress-responsive apoptosis signal-regulating kinase 1 (Ask1) in platelets results in unstable hemostasis and drastic attenuatio...

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Publicat a:Cell Death Differ
Autors principals: Kamiyama, Miki, Shirai, Toshiaki, Tamura, Shogo, Suzuki-Inoue, Katsue, Ehata, Shogo, Takahashi, Kei, Miyazono, Kohei, Hayakawa, Yoshihiro, Sato, Takehiro, Takeda, Kohsuke, Naguro, Isao, Ichijo, Hidenori
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
Matèries:
Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686340/
https://ncbi.nlm.nih.gov/pubmed/28753204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.114
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