Targeting cyclophilin-D by compound 19 protects neuronal cells from oxygen glucose deprivation/re-oxygenation

Oxygen and glucose deprivation (OGD) with re-oxygenation (OGDR) is applied to neuronal cells to mimic ischemia-reperfusion injuries. Activation of cyclophilin D (Cyp-D)-dependent programmed necrosis pathway mediates OGDR-induced neuronal cell damages. Here, we tested the potential effect of Compound...

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Udgivet i:Oncotarget
Main Authors: Zheng, Jinyu, Cui, Enhui, Yang, Haikou, Li, Mao, Zhou, Jing, Yan, Ming, Sun, Jian, Tang, De-Rong
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685745/
https://ncbi.nlm.nih.gov/pubmed/29163824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21655
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