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The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma

Monoclonal gammopathy of undetermined significance is a pre-malignant precursor of multiple myeloma with a 1% risk of progression per year. Although targeted analyses have shown the presence of specific genetic abnormalities such as IGH translocations, RB1 deletion, 1q gain, hyperdiploidy or RAS gen...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Mikulasova, Aneta, Wardell, Christopher P., Murison, Alexander, Boyle, Eileen M., Jackson, Graham H., Smetana, Jan, Kufova, Zuzana, Pour, Ludek, Sandecka, Viera, Almasi, Martina, Vsianska, Pavla, Gregora, Evzen, Kuglik, Petr, Hajek, Roman, Davies, Faith E., Morgan, Gareth J., Walker, Brian A.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685224/
https://ncbi.nlm.nih.gov/pubmed/28550183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.163766
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