PDGFR-modulated miR-23b cluster and miR-125a-5p suppress lung tumorigenesis by targeting multiple components of KRAS and NF-kB pathways

In NSCLC alterations in PDGF receptors are markers of worst prognosis and efficient targeting of these receptors is yet to be achieved. In this study, we explored PDGFR-regulated microRNAs demonstrating that miR-23b cluster and miR-125a-5p are downregulated by increased expression of PDGFR-α or PDGF...

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Publicado en:Sci Rep
Main Authors: Naidu, Srivatsava, Shi, Lei, Magee, Peter, Middleton, Justin D., Laganá, Alessandro, Sahoo, Sudhakar, Leong, Hui Sun, Galvin, Melanie, Frese, Kristopher, Dive, Caroline, Guzzardo, Vincenza, Fassan, Matteo, Garofalo, Michela
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684387/
https://ncbi.nlm.nih.gov/pubmed/29133857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14843-6
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