Store-operated Ca(2+) entry controls clonal expansion of T cells through metabolic reprogramming

Store-operated Ca(2+) entry (SOCE) is the main Ca(2+) influx pathway in lymphocytes and essential for T cell function and adaptive immunity. SOCE is mediated by Ca(2+) release-activated Ca(2+) (CRAC) channels that are activated by stromal interaction molecules (STIM) 1 and STIM2. SOCE regulates many...

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Udgivet i:Immunity
Main Authors: Vaeth, Martin, Maus, Mate, Klein-Hessling, Stefan, Freinkman, Elizaveta, Yang, Jun, Eckstein, Miriam, Cameron, Scott, Turvey, Stuart E., Serfling, Edgar, Berberich-Siebelt, Friederike, Possemato, Richard, Feske, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683398/
https://ncbi.nlm.nih.gov/pubmed/29030115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.09.003
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