Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells

Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA against CRC cells was little reported. Here, we proved that BA elicited CRC cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, BA treatment induced auto...

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Detalles Bibliográficos
Publicado en:Cell Death Dis
Main Authors: Wang, Sen, Wang, Kexin, Zhang, Chundong, Zhang, Wanfeng, Xu, Qian, Wang, Yitao, Zhang, Yulin, Li, Yi, Zhang, Ying, Zhu, Huifang, Song, Fangzhou, Lei, Yunlong, Bu, Youquan
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682653/
https://ncbi.nlm.nih.gov/pubmed/28981110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.485
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