Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages

Tumor-associated macrophages (TAMs) frequently help to sustain tumor growth and mediate immune suppression in the tumor microenvironment (TME). Here, we identified a subset of iron-loaded, pro-inflammatory TAMs localized in hemorrhagic areas of the TME. The occurrence of iron-loaded TAMs (iTAMs) cor...

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Pubblicato in:Front Immunol
Autori principali: Costa da Silva, Milene, Breckwoldt, Michael O., Vinchi, Francesca, Correia, Margareta P., Stojanovic, Ana, Thielmann, Carl Maximilian, Meister, Michael, Muley, Thomas, Warth, Arne, Platten, Michael, Hentze, Matthias W., Cerwenka, Adelheid, Muckenthaler, Martina U.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682327/
https://ncbi.nlm.nih.gov/pubmed/29167669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01479
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