Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain

CD40 agonists bind the CD40 molecule on antigen-presenting cells and activate them to prime tumor-specific CD8(+) T cell responses. Here, we study the antitumor activity and mechanism of action of a nonreplicating adenovirus encoding a chimeric, membrane-bound CD40 ligand (ISF35). Intratumoral admin...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Singh, Manisha, Vianden, Christina, Cantwell, Mark J., Dai, Zhimin, Xiao, Zhilan, Sharma, Meenu, Khong, Hiep, Jaiswal, Ashvin R., Faak, Faisal, Hailemichael, Yared, Janssen, L. M. E., Bharadwaj, Uddalak, Curran, Michael A., Diab, Adi, Bassett, Roland L., Tweardy, David J., Hwu, Patrick, Overwijk, Willem W.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682289/
https://ncbi.nlm.nih.gov/pubmed/29129918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01572-7
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