Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss

Age-related hearing loss is a major unresolved public health problem. We have previously elucidated that the activation of cochlear miR-34a is correlated with age-related hearing loss in C57BL/6 mice. A growing body of evidence points that aberrant autophagy promotes cell death during the developmen...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Pang, Jiaqi, Xiong, Hao, Lin, Peiliang, Lai, Lan, Yang, Haidi, Liu, Yimin, Huang, Qiuhong, Chen, Suijun, Ye, Yongyi, Sun, Yingfeng, Zheng, Yiqing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680584/
https://ncbi.nlm.nih.gov/pubmed/28981097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.462
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