Hypoxia-induced reactive oxygen species mediate N-cadherin and SERPINE1 expression, EGFR signalling and motility in MDA-MB-468 breast cancer cells

One of the hallmarks of the tumour microenvironment is hypoxia resulting from increased oxygen consumption by proliferative cancer cells and altered vasculature. Hypoxic tension initiates various cellular signals and can drive epithelial to mesenchymal transition (EMT), a process important in cancer...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Azimi, Iman, Petersen, Rosalie M., Thompson, Erik W., Roberts-Thomson, Sarah J., Monteith, Gregory R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680275/
https://ncbi.nlm.nih.gov/pubmed/29123322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15474-7
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