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Paclitaxel reduces axonal Bclw to initiate IP(3)R1-dependent axon degeneration
Chemotherapy induced peripheral neuropathy (CIPN) is a debilitating side effect of many cancer treatments. The hallmark of CIPN is degeneration of long axons required for transmission of sensory information; axonal degeneration causes impaired tactile sensation and persistent pain. Currently the mol...
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| 發表在: | Neuron |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5680044/ https://ncbi.nlm.nih.gov/pubmed/29024661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.09.034 |
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