Vascular ADAM17 is required for angiotensin II/β-aminopropionitrile-induced abdominal aortic aneurysm

Angiotensin II (AngII)-activated epidermal growth factor receptor (EGFR) has been implicated in abdominal aortic aneurysm (AAA) development. In vascular smooth muscle cells (VSMC), AngII activates EGFR via a metalloproteinase, a disintegrin and metallopeptidase domain 17 (ADAM17). We hypothesized th...

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Bibliographic Details
Published in:Hypertension
Main Authors: Kawai, Tatsuo, Takayanagi, Takehiko, Forrester, Steven J., Preston, Kyle J., Obama, Takashi, Tsuji, Toshiyuki, Kobayashi, Tomonori, Boyer, Michael J., Cooper, Hannah A., Kwok, Hang Fai, Hashimoto, Tomoki, Scalia, Rosario, Rizzo, Victor, Eguchi, Satoru
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679456/
https://ncbi.nlm.nih.gov/pubmed/28947615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09822
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