Temporal Control of Mammalian Cortical Neurogenesis by m(6)A Methylation

N(6)-methyladenosine (m(6)A), installed by the Mettl3/Mettl14 methyltransferase complex, is the most prevalent internal mRNA modification. Whether m(6)A regulates mammalian brain development is unknown. Here we show that m(6)A depletion by Mettl14 knockout in embryonic mouse brains prolongs cell cyc...

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Bibliographic Details
Published in:Cell
Main Authors: Yoon, Ki-Jun, Ringeling, Francisca Rojas, Vissers, Caroline, Jacob, Fadi, Pokrass, Michael, Jimenez-Cyrus, Dennisse, Su, Yijing, Kim, Nam-Shik, Zhu, Yunhua, Zheng, Lily, Kim, Sunghan, Wang, Xinyuan, Doré, Louis C., Jin, Peng, Regot, Sergi, Zhuang, Xiaoxi, Canzar, Stefan, He, Chuan, Ming, Guo-li, Song, Hongjun
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679435/
https://ncbi.nlm.nih.gov/pubmed/28965759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.003
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