Temporal Control of Mammalian Cortical Neurogenesis by m(6)A Methylation

N(6)-methyladenosine (m(6)A), installed by the Mettl3/Mettl14 methyltransferase complex, is the most prevalent internal mRNA modification. Whether m(6)A regulates mammalian brain development is unknown. Here we show that m(6)A depletion by Mettl14 knockout in embryonic mouse brains prolongs cell cyc...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Yoon, Ki-Jun, Ringeling, Francisca Rojas, Vissers, Caroline, Jacob, Fadi, Pokrass, Michael, Jimenez-Cyrus, Dennisse, Su, Yijing, Kim, Nam-Shik, Zhu, Yunhua, Zheng, Lily, Kim, Sunghan, Wang, Xinyuan, Doré, Louis C., Jin, Peng, Regot, Sergi, Zhuang, Xiaoxi, Canzar, Stefan, He, Chuan, Ming, Guo-li, Song, Hongjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679435/
https://ncbi.nlm.nih.gov/pubmed/28965759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.003
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