Temporal Control of Mammalian Cortical Neurogenesis by m(6)A Methylation

N(6)-methyladenosine (m(6)A), installed by the Mettl3/Mettl14 methyltransferase complex, is the most prevalent internal mRNA modification. Whether m(6)A regulates mammalian brain development is unknown. Here we show that m(6)A depletion by Mettl14 knockout in embryonic mouse brains prolongs cell cyc...

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Bibliografske podrobnosti
izdano v:Cell
Main Authors: Yoon, Ki-Jun, Ringeling, Francisca Rojas, Vissers, Caroline, Jacob, Fadi, Pokrass, Michael, Jimenez-Cyrus, Dennisse, Su, Yijing, Kim, Nam-Shik, Zhu, Yunhua, Zheng, Lily, Kim, Sunghan, Wang, Xinyuan, Doré, Louis C., Jin, Peng, Regot, Sergi, Zhuang, Xiaoxi, Canzar, Stefan, He, Chuan, Ming, Guo-li, Song, Hongjun
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679435/
https://ncbi.nlm.nih.gov/pubmed/28965759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.003
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