Temporal Control of Mammalian Cortical Neurogenesis by m(6)A Methylation

N(6)-methyladenosine (m(6)A), installed by the Mettl3/Mettl14 methyltransferase complex, is the most prevalent internal mRNA modification. Whether m(6)A regulates mammalian brain development is unknown. Here we show that m(6)A depletion by Mettl14 knockout in embryonic mouse brains prolongs cell cyc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell
Prif Awduron: Yoon, Ki-Jun, Ringeling, Francisca Rojas, Vissers, Caroline, Jacob, Fadi, Pokrass, Michael, Jimenez-Cyrus, Dennisse, Su, Yijing, Kim, Nam-Shik, Zhu, Yunhua, Zheng, Lily, Kim, Sunghan, Wang, Xinyuan, Doré, Louis C., Jin, Peng, Regot, Sergi, Zhuang, Xiaoxi, Canzar, Stefan, He, Chuan, Ming, Guo-li, Song, Hongjun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679435/
https://ncbi.nlm.nih.gov/pubmed/28965759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.003
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