Effect of Losartan on Mitral Valve Changes After Myocardial Infarction

BACKGROUND: After myocardial infarction (MI), mitral valve (MV) tethering stimulates adaptive leaflet growth, but counterproductive leaflet thickening and fibrosis augment mitral regurgitation (MR), doubling heart failure and mortality. MV fibrosis post-MI is associated with excessive endothelial-to...

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Gepubliceerd in:J Am Coll Cardiol
Hoofdauteurs: Bartko, Philipp E., Dal-Bianco, Jacob P., Guerrero, J. Luis, Beaudoin, Jonathan, Szymanski, Catherine, Kim, Dae-Hee, Seybolt, Margo M., Handschumacher, Mark D., Sullivan, Suzanne, Garcia, Michael L., Titus, James S., Wylie-Sears, Jill, Irvin, Whitney S., Messas, Emmanuel, Hagège, Albert A., Carpentier, Alain, Aikawa, Elena, Bischoff, Joyce, Levine, Robert A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679094/
https://ncbi.nlm.nih.gov/pubmed/28859786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2017.07.734
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