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The Impact of Non-Vitamin K Antagonist Oral Anticoagulants (NOACs) from a Basic Science Perspective

1. Inhibiting a single protease is much less “effective” at inhibiting coagulation than is inhibiting at multiple steps. Thus, the dose-response relationship between NOAC level and intensity of anti-coagulation is shallower and more linear than that of vitamin K antagonists. This partially accounts...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Hoffman, Maureane, Monroe, Dougald M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678960/
https://ncbi.nlm.nih.gov/pubmed/28798139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.306995
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