Asian Zika virus strains target CD14(+) blood monocytes and induce M2-skewed immunosuppression during pregnancy

Blood CD14(+) monocytes are the frontline immunomodulators categorized into classical, intermediate or non-classical subsets, subsequently differentiating into M1 pro- or M2 anti-inflammatory macrophages upon stimulation. While Zika virus (ZIKV) rapidly establishes viremia, the target cells and immu...

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Udgivet i:Nat Microbiol
Main Authors: Foo, Suan-Sin, Chen, Weiqiang, Chan, Yen, Bowman, James W., Chang, Lin-Chun, Choi, Younho, Yoo, Ji Seung, Ge, Jianning, Cheng, Genhong, Bonnin, Alexandre, Nielsen-Saines, Karin, Brasil, Patrícia, Jung, Jae U.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678934/
https://ncbi.nlm.nih.gov/pubmed/28827581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-017-0016-3
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