BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination

The ATPase activity of NLRP3 has pivotal role in inflammasome activation and is recognized as a good target for the development of the NLRP3 inflammasome-specific inhibitor. However, signals in the vicinity of the ATPase activity of NLRP3 have not been fully elucidated. Here, we demonstrate NLRP3 in...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Shim, Do-Wan, Shin, Woo-Young, Yu, Sang-Hyeun, Kim, Byung-Hak, Ye, Sang-Kyu, Koppula, Sushruta, Won, Hyung-Sik, Kang, Tae-Bong, Lee, Kwang-Ho
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678161/
https://ncbi.nlm.nih.gov/pubmed/29118366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15314-8
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