Mesenchymal stem cells internalize Mycobacterium tuberculosis through scavenger receptors and restrict bacterial growth through autophagy

Human mesenchymal stem cells (MSCs) express scavenger receptors that internalize lipids, including oxidized low-density lipoprotein (oxLDL). We report that MSCs phagocytose Mycobacterium tuberculosis (Mtb) through two types of scavenger receptors (SRs; MARCO and SR-B1), as blockade of the receptors...

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Pubblicato in:Sci Rep
Autori principali: Khan, Arshad, Mann, Lovepreet, Papanna, Ramesha, Lyu, Mi-Ae, Singh, Christopher R., Olson, Scott, Eissa, N. Tony, Cirillo, Jeffrey, Das, Gobardhan, Hunter, Robert L., Jagannath, Chinnaswamy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678154/
https://ncbi.nlm.nih.gov/pubmed/29118429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15290-z
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