Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner

While blocking tumor growth by targeting autophagy is well established, its role on the infiltration of natural killer (NK) cells into tumors remains unknown. Here, we investigate the impact of targeting autophagy gene Beclin1 (BECN1) on the infiltration of NK cells into melanomas. We show that, in...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mgrditchian, Takouhie, Arakelian, Tsolere, Paggetti, Jérôme, Noman, Muhammad Zaeem, Viry, Elodie, Moussay, Etienne, Van Moer, Kris, Kreis, Stephanie, Guerin, Coralie, Buart, Stephanie, Robert, Caroline, Borg, Christophe, Vielh, Philippe, Chouaib, Salem, Berchem, Guy, Janji, Bassam
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676879/
https://ncbi.nlm.nih.gov/pubmed/29078276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703921114
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