Leptin regulates Granzyme-A, PD-1 and CTLA-4 expression in T cell to control visceral leishmaniasis in BALB/c Mice

Visceral leishmaniasis (VL) is responsible for several deaths in malnourished children accompanied by diminished circulating leptin and impaired cell-mediated immunity. Typically, leptin deficiency is associated with the Th2 polarization that markedly coincides with the pathogenesis of VL. The aim o...

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Vydáno v:Sci Rep
Hlavní autoři: Dayakar, Alti, Chandrasekaran, Sambamurthy, Veronica, Jalaja, Bharadwaja, Vadloori, Maurya, Radheshyam
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676676/
https://ncbi.nlm.nih.gov/pubmed/29116252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15288-7
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