Combinations of QTc-prolonging drugs: towards disentangling pharmacokinetic and pharmacodynamic effects in their potentially additive nature

BACKGROUND: Whether arrhythmia risks will increase if drugs with electrocardiographic (ECG) QT-prolonging properties are combined is generally supposed but not well studied. Based on available evidence, the Arizona Center for Education and Research on Therapeutics (AZCERT) classification defines the...

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Publicat a:Ther Adv Psychopharmacol
Autors principals: Meid, Andreas D., Bighelli, Irene, Mächler, Sarah, Mikus, Gerd, Carrà, Giuseppe, Castellazzi, Mariasole, Lucii, Claudio, Martinotti, Giovanni, Nosè, Michela, Ostuzzi, Giovanni, Barbui, Corrado, Haefeli, Walter E.
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2017
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676495/
https://ncbi.nlm.nih.gov/pubmed/29201344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2045125317721662
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