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Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity
Griselimycins (GMs) are depsidecapeptides with superb anti-tuberculosis activity. They contain up to three (2S,4R)-4-methyl-prolines (4-MePro), of which one blocks oxidative degradation and increases metabolic stability in animal models. The natural congener with this substitution is only a minor co...
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| 出版年: | Chem Sci |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Royal Society of Chemistry
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5676206/ https://ncbi.nlm.nih.gov/pubmed/29163906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc02622f |
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