An Unexpected Major Role for Proteasome-Catalyzed Peptide Splicing in Generation of T Cell Epitopes: Is There Relevance for Vaccine Development?

Efficient and safe induction of CD8(+) T cell responses is a desired characteristic of vaccines against intracellular pathogens. To achieve this, a new generation of safe vaccines is being developed accommodating single, dominant antigens of pathogens of interest. In particular, the selection of suc...

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發表在:Front Immunol
Main Authors: Platteel, Anouk C. M., Liepe, Juliane, van Eden, Willem, Mishto, Michele, Sijts, Alice J. A. M.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2017
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675849/
https://ncbi.nlm.nih.gov/pubmed/29163514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01441
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