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Blocking Bcl-2 Resolves IL-13–Mediated Mucous Cell Hyperplasia in a Bik-Dependent Manner
Because IL-13 induces expression of the anti-apoptotic Bcl-2 and the pro-apoptotic Bik, blocking Bcl-2 causes a Bik-dependent death of hyperplastic mucous cells. Therefore, the Bcl-2-inhibitor, ABT-263, may be highly efficient in reducing mucous hypersecretion.
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| Publicado no: | J Allergy Clin Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5675799/ https://ncbi.nlm.nih.gov/pubmed/28784260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.05.038 |
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