A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina

The majority of inherited retinal degenerations converge on the phenotype of photoreceptor cell death. Second- and third-order neurons are spared in these diseases, making it possible to restore retinal light responses using optogenetics. Viral expression of channelrhodopsin in the third-order neuro...

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Dettagli Bibliografici
Pubblicato in:Mol Ther
Autori principali: Chaffiol, Antoine, Caplette, Romain, Jaillard, Céline, Brazhnikova, Elena, Desrosiers, Mélissa, Dubus, Elisabeth, Duhamel, Laëtitia, Macé, Emilie, Marre, Olivier, Benoit, Patrick, Hantraye, Philippe, Bemelmans, Alexis-Pierre, Bamberg, Ernst, Duebel, Jens, Sahel, José-Alain, Picaud, Serge, Dalkara, Deniz
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675708/
https://ncbi.nlm.nih.gov/pubmed/28807567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.07.011
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