Ubiquitylation-independent activation of Notch signalling by Delta

Ubiquitylation (ubi) by the E3-ligases Mindbomb1 (Mib1) and Neuralized (Neur) is required for activation of the DSL ligands Delta (Dl) and Serrate (Ser) to activate Notch signalling. These ligases transfer ubiquitin to lysines of the ligands' intracellular domains (ICDs), which sends them into...

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Pubblicato in:eLife
Autori principali: Berndt, Nicole, Seib, Ekaterina, Kim, Soya, Troost, Tobias, Lyga, Marvin, Langenbach, Jessica, Haensch, Sebastian, Kalodimou, Konstantina, Delidakis, Christos, Klein, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675594/
https://ncbi.nlm.nih.gov/pubmed/28960177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27346
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