Ubiquitylation-independent activation of Notch signalling by Delta

Ubiquitylation (ubi) by the E3-ligases Mindbomb1 (Mib1) and Neuralized (Neur) is required for activation of the DSL ligands Delta (Dl) and Serrate (Ser) to activate Notch signalling. These ligases transfer ubiquitin to lysines of the ligands' intracellular domains (ICDs), which sends them into...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Berndt, Nicole, Seib, Ekaterina, Kim, Soya, Troost, Tobias, Lyga, Marvin, Langenbach, Jessica, Haensch, Sebastian, Kalodimou, Konstantina, Delidakis, Christos, Klein, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675594/
https://ncbi.nlm.nih.gov/pubmed/28960177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27346
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