Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors

The Zfp423/ZNF423 gene encodes a 30-zinc-finger transcription factor involved in key developmental pathways. Although null Zfp423 mutants develop cerebellar malformations, the underlying mechanism remains unknown. ZNF423 mutations are associated with Joubert Syndrome, a ciliopathy causing cerebellar...

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Vydáno v:Development
Hlavní autoři: Casoni, Filippo, Croci, Laura, Bosone, Camilla, D'Ambrosio, Roberta, Badaloni, Aurora, Gaudesi, Davide, Barili, Valeria, Sarna, Justyna R., Tessarollo, Lino, Cremona, Ottavio, Hawkes, Richard, Warming, Søren, Consalez, G. Giacomo
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2017
Témata:
Stem Cells and Regeneration
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675449/
https://ncbi.nlm.nih.gov/pubmed/28893945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.155077
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