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A novel intracellular pool of LFA-1 is critical for asymmetric CD8(+) T cell activation and differentiation
The integrin lymphocyte function–associated antigen 1 (LFA-1; CD11a/CD18) is a key T cell adhesion receptor that mediates stable interactions with antigen-presenting cell (APC), as well as chemokine-mediated migration. Using our newly generated CD11a-mYFP knock-in mice, we discovered that naive CD8(...
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| Publié dans: | J Cell Biol |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5674876/ https://ncbi.nlm.nih.gov/pubmed/28954823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201609072 |
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