Correlation of tumor mutational burden and treatment outcomes in patients with colorectal cancer

BACKGROUND: The Cancer Genome Atlas (TCGA) showed that 16% of colorectal cancers (CRCs) display DNA repair mechanisms and high tumor mutational burden (TMB). Although, there is accumulating evidence of greater benefit of immunotherapy in tumors with high-TMB, its impact on response to chemotherapy i...

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Detalhes bibliográficos
Publicado no:J Gastrointest Oncol
Main Authors: Pai, Sachin G., Carneiro, Benedito A., Chae, Young Kwang, Costa, Ricardo L., Kalyan, Aparna, Shah, Hiral A., Helenowski, Irene, Rademaker, Alfred W., Mahalingam, Devalingam, Giles, Francis J.
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674261/
https://ncbi.nlm.nih.gov/pubmed/29184690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jgo.2017.06.20
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