Tissue Factor-Expressing Tumor-Derived Extracellular Vesicles Activate Quiescent Endothelial Cells via Protease-Activated Receptor-1

Tissue factor (TF)-expressing tumor-derived extracellular vesicles (EVs) can promote metastasis and pre-metastatic niche formation, but the mechanisms by which this occurs remain largely unknown. We hypothesized that generation of activated factor X (FXa) by TF expressed on tumor-derived EV could ac...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Che, Sara P. Y., Park, Jeannie Y., Stokol, Tracy
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673848/
https://ncbi.nlm.nih.gov/pubmed/29164060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2017.00261
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