Downregulation of DmMANF in Glial Cells Results in Neurodegeneration and Affects Sleep and Lifespan in Drosophila melanogaster

In Drosophila melanogaster, mesencephalic astrocyte-derived neurotrophic factor (DmMANF) is an evolutionarily conserved ortholog of mammalian MANF and cerebral dopamine neurotrophic factor (CDNF), which have been shown to promote the survival of dopaminergic neurons in the brain. We observed especia...

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Bibliographic Details
Published in:Front Neurosci
Main Authors: Walkowicz, Lucyna, Kijak, Ewelina, Krzeptowski, Wojciech, Górska-Andrzejak, Jolanta, Stratoulias, Vassilis, Woznicka, Olga, Chwastek, Elzbieta, Heino, Tapio I., Pyza, Elzbieta M.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673640/
https://ncbi.nlm.nih.gov/pubmed/29163014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00610
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