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Preliminary studies on the use of pertussis toxin for the modulation of intra-vaginal SIV transmission in rhesus macaques
BACKGROUND: Pertussis toxin (PTX) blocks GPCR signaling resulting in the inhibition of chemotaxis /cell adhesion. It was reasoned that inhibition of cell trafficking may be an approach to prevent HIV/SIV transmission. METHODS: In this study PTX in HEC gel was applied to the vaginal wall of monkeys t...
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| Опубликовано в: : | J Med Primatol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5673538/ https://ncbi.nlm.nih.gov/pubmed/28940591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jmp.12316 |
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