A novel inhibitory anti-invasive MAb isolated using phenotypic screening highlights AnxA6 as a functionally relevant target protein in pancreatic cancer

BACKGROUND: Discovery and validation of new antibody tractable targets is critical for the development of new antibody therapeutics to address unmet needs in oncology. METHODS: A highly invasive clonal variant of the MDA-MB-435S cell line was used to generate monoclonal antibodies (MAbs), which were...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: O'Sullivan, Dermot, Dowling, Paul, Joyce, Helena, McAuley, Edel, McCann, Andrew, Henry, Michael, McGovern, Brianan, Barham, Paul, Kelleher, Fergal C, Murphy, Jean, Kennedy, Susan, Swan, Niall, Moriarty, Michael, Clynes, Martin, Larkin, Annemarie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672937/
https://ncbi.nlm.nih.gov/pubmed/28881357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.306
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados