Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage

We have previously shown that the insulin-like growth factor 1 receptor (IGF-1R) translocates to the cell nucleus, where it binds to enhancer-like regions and increases gene transcription. Further studies have demonstrated that nuclear IGF-1R (nIGF-1R) physically and functionally interacts with some...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Waraky, Ahmed, Lin, Yingbo, Warsito, Dudi, Haglund, Felix, Aleem, Eiman, Larsson, Olle
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672045/
https://ncbi.nlm.nih.gov/pubmed/28924044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.781492
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