Inflammatory responses induce an identity crisis of alveolar macrophages, leading to pulmonary alveolar proteinosis

Pulmonary alveolar proteinosis (PAP) is a severe respiratory disease characterized by dyspnea caused by accumulation of surfactant protein. Dysfunction of alveolar macrophages (AMs), which regulate the homeostasis of surfactant protein, leads to the development of PAP; for example, in mice lacking B...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Ebina-Shibuya, Risa, Matsumoto, Mitsuyo, Kuwahara, Makoto, Jang, Kyoung-Jin, Sugai, Manabu, Ito, Yoshiaki, Funayama, Ryo, Nakayama, Keiko, Sato, Yuki, Ishii, Naoto, Okamura, Yasunobu, Kinoshita, Kengo, Kometani, Kohei, Kurosaki, Tomohiro, Muto, Akihiko, Ichinose, Masakazu, Yamashita, Masakatsu, Igarashi, Kazuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672035/
https://ncbi.nlm.nih.gov/pubmed/28916727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808535
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