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A Simple Light Isotope Metabolic Labeling (SLIM-labeling) Strategy: A Powerful Tool to Address the Dynamics of Proteome Variations In Vivo

Many quantitative proteomics strategies rely on in vivo metabolic incorporation of amino acids with modified stable isotope profiles into proteins. These methods give rise to multiple ions for each peptide, with possible distortion of the isotopolog distribution, making the overall analytical proces...

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Bibliographic Details
Published in:Mol Cell Proteomics
Main Authors: Léger, Thibaut, Garcia, Camille, Collomb, Laetitia, Camadro, Jean-Michel
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672006/
https://ncbi.nlm.nih.gov/pubmed/28821603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M117.066936
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