Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer

BACKGROUND: Pigs have many features that make them attractive as biomedical models for various diseases, including cancer. P53 is an important tumor suppressor gene that exerts a central role in protecting cells from oncogenic transformation and is mutated in a large number of human cancers. P53 mut...

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Vydáno v:J Transl Med
Hlavní autoři: Shen, Youfeng, Xu, Kaixiang, Yuan, Zaimei, Guo, Jianxiong, Zhao, Heng, Zhang, Xuezeng, Zhao, Lu, Qing, Yubo, Li, Honghui, Pan, Weirong, Jia, Baoyu, Zhao, Hong-Ye, Wei, Hong-Jiang
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670695/
https://ncbi.nlm.nih.gov/pubmed/29100547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1327-0
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