Effect of diabetes status and hyperglycemia on global DNA methylation and hydroxymethylation

Type 2 diabetes mellitus (T2DM) is characterized by oxidative stress that could lead to chronic micro- and macrovascular complications. We hypothesized that some of the target organ damage is mediated by oxidative alterations in epigenetic mechanisms involving DNA methylation (5mC) and DNA hydroxyme...

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Bibliographic Details
Published in:Endocr Connect
Main Authors: Pinzón-Cortés, Jairo Arturo, Perna-Chaux, Angelina, Rojas-Villamizar, Nicolás Steven, Díaz-Basabe, Angélica, Polanía-Villanueva, Diana Carolina, Jácome, María Fernanda, Mendivil, Carlos Olimpo, Groot, Helena, López-Segura, Valeriano
Format: Artigo
Language:Inglês
Published: Bioscientifica Ltd 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670276/
https://ncbi.nlm.nih.gov/pubmed/28993426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EC-17-0199
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