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Identification of a peptide-peptide binding motif in the coating of nab-paclitaxel nanoparticles with clinical antibodies: bevacizumab, rituximab, and trastuzumab

Antibody directed chemotherapy (ADC) takes advantage of the selectivity of the monoclonal antibody to increase the efficacy of the chemotherapeutic agent, while reducing toxicity. Previously we described three nab-paclitaxel (Abraxane) nanoparticles coated with commercial monoclonal antibodies. Iden...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Butterfield, John T., Kim, Hidong, Knauer, Daniel J., Nevala, Wendy K., Markovic, Svetomir N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670201/
https://ncbi.nlm.nih.gov/pubmed/29101359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15251-6
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