Inhibition of cell cycle progression by the hydroxytyrosol–cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells

Hydroxytyrosol (HT), a polyphenol of olive oil, downregulates epidermal growth factor (EGFR) expression and inhibits cell proliferation in colon cancer (CC) cells, with mechanisms similar to that activated by the EGFR inhibitor, cetuximab. Here, we studied whether HT treatment would enhance the cetu...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Terzuoli, Erika, Nannelli, Ginevra, Frosini, Maria, Giachetti, Antonio, Ziche, Marina, Donnini, Sandra
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669961/
https://ncbi.nlm.nih.gov/pubmed/29137335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20544
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