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Inhibition of cell cycle progression by the hydroxytyrosol–cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells

Hydroxytyrosol (HT), a polyphenol of olive oil, downregulates epidermal growth factor (EGFR) expression and inhibits cell proliferation in colon cancer (CC) cells, with mechanisms similar to that activated by the EGFR inhibitor, cetuximab. Here, we studied whether HT treatment would enhance the cetu...

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Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Terzuoli, Erika, Nannelli, Ginevra, Frosini, Maria, Giachetti, Antonio, Ziche, Marina, Donnini, Sandra
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669961/
https://ncbi.nlm.nih.gov/pubmed/29137335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20544
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