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In Situ-Generated Glycinyl Chloroaminals for a One-Pot Synthesis of Non-proteinogenic α-Amino Esters

An acetyl chloride-mediated cascade transformation involving a primary carbamate, ethyl glyoxylate, and various types of nucleophiles is reported for the synthesis of orthogonally protected α-amino esters. These reactions proceeded rapidly to afford the pivotal α-chloroglycine intermediate in excell...

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Bibliografiske detaljer
Udgivet i:J Org Chem
Main Authors: Samanta, Shyam S., Roche, Stéphane P.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669263/
https://ncbi.nlm.nih.gov/pubmed/28737944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b01274
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