Targeting of Extracellular RNA Reduces Edema Formation and Infarct Size and Improves Survival After Myocardial Infarction in Mice

BACKGROUND: Following myocardial infarction (MI), peri‐infarct myocardial edema formation further impairs cardiac function. Extracellular RNA (eRNA) released from injured cells strongly increases vascular permeability. This study aimed to assess the role of eRNA in MI‐induced cardiac edema formation...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Stieger, Philipp, Daniel, Jan‐Marcus, Thölen, Christiane, Dutzmann, Jochen, Knöpp, Kai, Gündüz, Dursun, Aslam, Muhammad, Kampschulte, Marian, Langheinrich, Alexander, Fischer, Silvia, Cabrera‐Fuentes, Hector, Wang, Yong, Wollert, Kai C., Bauersachs, Johann, Braun‐Dullaeus, Rüdiger, Preissner, Klaus T., Sedding, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669142/
https://ncbi.nlm.nih.gov/pubmed/28637776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.004541
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