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Single-cell sequencing data reveal widespread recurrence and loss of mutational hits in the life histories of tumors

Intra-tumor heterogeneity poses substantial challenges for cancer treatment. A tumor's composition can be deduced by reconstructing its mutational history. Central to current approaches is the infinite sites assumption that every genomic position can only mutate once over the lifetime of a tumo...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Kuipers, Jack, Jahn, Katharina, Raphael, Benjamin J., Beerenwinkel, Niko
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668945/
https://ncbi.nlm.nih.gov/pubmed/29030470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.220707.117
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