Validation and characterization of a novel method for selective vagal deafferentation of the gut

There is a lack of tools that selectively target vagal afferent neurons (VAN) innervating the gut. We use saporin (SAP), a potent neurotoxin, conjugated to the gastronintestinal (GI) hormone cholecystokinin (CCK-SAP) injected into the nodose ganglia (NG) of male Wistar rats to specifically ablate GI...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Diepenbroek, Charlene, Quinn, Danielle, Stephens, Ricky, Zollinger, Benjamin, Anderson, Seth, Pan, Annabelle, de Lartigue, Guillaume
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668568/
https://ncbi.nlm.nih.gov/pubmed/28705805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00095.2017
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