Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis

Platelets can be found on the surface of inflamed and ruptured atherosclerotic plaques. Thus, targeting of activated platelets may allow for molecular imaging of vulnerable atherosclerotic lesions. We here investigated microbubbles (MB) functionalized with the selectin ligand sialyl Lewis(a) individ...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Günther, F., Heidt, T., Kramer, M., Khanicheh, E., Klibanov, A. L., Geibel-Zehender, A., Ferrante, E. A., Hilgendorf, I., Wolf, D., Zirlik, A., Reinöhl, J., Bode, C., Peter, K., Kaufmann, B. A., Mühlen, C. von zur
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668440/
https://ncbi.nlm.nih.gov/pubmed/29097799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15080-7
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