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A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents
Dph3 is involved in diphthamide modification of the eukaryotic translation elongation factor eEF2 and in Elongator-mediated modifications of tRNAs, where a 5-methoxycarbonyl-methyl moiety is added to wobble uridines. Lack of such modifications affects protein synthesis due to inaccurate translation...
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| Pubblicato in: | Curr Genet |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer Berlin Heidelberg
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5668335/ https://ncbi.nlm.nih.gov/pubmed/28555368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00294-017-0711-x |
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