A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair

As central nodes in cardiomyocyte signaling, nuclear AKT appears to play a cardio-protective role in cardiovascular disease. Here we describe a circular RNA, circ-Amotl1 that is highly expressed in neonatal human cardiac tissue, and potentiates AKT-enhanced cardiomyocyte survival. We hypothesize tha...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Zeng, Yan, Du, William W., Wu, Yingya, Yang, Zhenguo, Awan, Faryal Mehwish, Li, Xiangmin, Yang, Weining, Zhang, Chao, Yang, Qi, Yee, Albert, Chen, Yu, Yang, Fenghua, Sun, Huan, Huang, Ren, Yee, Albert J, Li, Ren-Ke, Wu, Zhongkai, Backx, Peter H, Yang, Burton B
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667408/
https://ncbi.nlm.nih.gov/pubmed/29109781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.19764
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